总揽：Will&； Grace is her best friend. Will is a gay lawyer and Grace is a heterosexuality interior designer. They all live in New York. Grace was engaged to a real jerk, but when the relationship broke down, she cohabited with Will. This can only wait until Grace finds her place to live, but she and Will eventually become permanent roommates. In the cast, there are also Will's openly gay friends Jack and Grace's secretary/assistant Karen, who actually don't need to work because she has been married several times.
